Casal J., Storer F., and Lawrence, P.A. Planar cell polarity: intracellular asymmetry and supracellular gradients of Frizzled. Open Biology 13: 230105 (2023).
Chorro A., Verma B., Homfeldt M., Ibáñez B., Lawrence P.A., and Casal J. Planar cell polarity: intracellular asymmetry and supracellular gradients of Dachsous Open Biology 12: 20195 (2022)
The slope of a supracellular molecular gradient has long been thought to orient and coordinate planar cell polarity (PCP). Here we demonstrate and measure that gradient. Dachsous (Ds) is a conserved and elemental molecule of PCP; Ds forms intercellular bridges with another cadherin molecule,
We are applying for grants to support our research during the 2021-2023 period. Any prospective student willing to do a PhD with us should contact us in November or December 2020.
A preprint of our last article is deposited in bioRxiv:
Pietra S., Ng K., Lawrence P.A. and Casal J. How do Dachsous and Fat polarise cells in the larval abdomen of Drosophila? bioRxiv (2020).